二氧化碳麻醉是通過直接或間接的缺氧引起動(dòng)物死亡的它可以在各種場所使用并可以不同的速度使動(dòng)物失去意識。要想達(dá)到苦、無疼痛的死亡就要在動(dòng)作(肌肉活動(dòng))消失之前喪失意識。但是動(dòng)作消失并不等同于喪失意識和沒有痛苦。因此只能引起肌肉麻痹而不能使動(dòng)物喪失意識的藥物不能作為單獨(dú)的藥物。二氧化碳法可能使動(dòng)物在喪失意識之后產(chǎn)生運(yùn)動(dòng)活動(dòng)但這些運(yùn)動(dòng)活動(dòng)只是反射活動(dòng)不能被動(dòng)物感知。因此可以獨(dú)立的作為方法。  

傳統(tǒng)的斷頭、放血等動(dòng)物致死方式方法比較殘忍容易對實(shí)驗(yàn)人員的心理產(chǎn)生負(fù)面影響；麻醉致死的方法更不可能本身易燃易爆并且有很強(qiáng)的致癌性對實(shí)驗(yàn)人員傷害更大。二氧化碳安全性高也能有效減少實(shí)驗(yàn)動(dòng)物的疼痛和痛苦。

 該系統(tǒng)體積小巧占地空間小可有效減少二氧化碳的使用易學(xué)易用操作簡單。

二氧化碳麻醉方式更符合動(dòng)物福利。

自動(dòng)型動(dòng)物系統(tǒng)

型號CL-1000型

CL-1000型小動(dòng)物系統(tǒng)采用自動(dòng)化控制的二氧化碳缺氧致死的方式控制和增加箱體內(nèi)二氧化碳的濃度并在達(dá)到一定的濃度后自動(dòng)切斷氣源維持一定的誘導(dǎo)時(shí)間在沒有驚擾、極輕微的痛苦中對動(dòng)物進(jìn)行快速的誘導(dǎo)死亡。

CL-1000型小動(dòng)物系統(tǒng)與常規(guī)型手控流量控制式箱相比較有明顯的優(yōu)勢

使用便捷自動(dòng)化程度高一鍵式完成操作；

省事省力系統(tǒng)可自動(dòng)進(jìn)行充氣、維持和清除廢氣的作業(yè)；

參數(shù)可調(diào)流速、通氣時(shí)間、維持時(shí)間、廢氣清洗時(shí)間可調(diào)可控；

使用更安全自動(dòng)清除箱體內(nèi)的大量二氧化碳和廢氣確保實(shí)驗(yàn)室的安全可連續(xù)進(jìn)行多批次的實(shí)驗(yàn)操作；

一體式小動(dòng)物系統(tǒng)

型號CL-2000

主要特點(diǎn)

· 設(shè)備為一體式設(shè)計(jì)可隔放在實(shí)驗(yàn)臺(tái)上使用

· 系統(tǒng)可預(yù)設(shè)程序自動(dòng)往箱內(nèi)通入設(shè)定量的二氧化碳

· 多種參數(shù)可進(jìn)行設(shè)置流速、通氣時(shí)間、維持時(shí)間、廢氣沖洗時(shí)間紫外殺菌時(shí)間

· 設(shè)置參數(shù)后可一鍵式操作即可完成動(dòng)物麻醉、、廢氣清除的整個(gè)操作過程中無需有人值守

· 二氧化碳?xì)怏w通入流速0-50L/min數(shù)字化顯示調(diào)控精度為0.01L/min

· 設(shè)備具有CO2傳感器能實(shí)時(shí)檢測箱體內(nèi)CO2濃度并可調(diào)節(jié)和控制箱體內(nèi)CO2的濃度

· 全觸摸屏操作人性化界面設(shè)計(jì)顯示屏上可同屏顯示多種運(yùn)行狀態(tài)

手動(dòng)型箱

多種型號可選也可根據(jù)實(shí)驗(yàn)室需求訂做更適合的方案敬請

定制型箱

無二氧化碳廢氣泄露適合SPF屏障實(shí)驗(yàn)室

型號LC-800-S1

部分參考文獻(xiàn)

1. Li J, Zhang Z, Qiu J, Huang X. 8-Methoxypsoralen has Anti-inflammatory and Antioxidant Roles in Osteoarthritis Through SIRT1/NF-κB Pathway. Frontiers in Pharmacology. 2021-September-06 2021;12.
2. Xu L, Wang S, Shen H, et al. Analgesic and toxic effects of venenum bufonis and its constituent compound cinobufaginA comparative study. Neurotoxicology and Teratology. 2019;73:49-53.
3. Tian J, Zhou D, Xiang L, et al. Calycosin represses AIM2 inflammasome-mediated inflammation and pyroptosis to attenuate monosodium urate-induced gouty arthritis through NF-κB and p62-Keap1 pathways. Drug Development Research. 2022/11/01 2022;83(7):1654-1672.
4. Li Y, Yu H, Lv M, Li Q, Zou K, Lv S. Combination therapy with budesonide and N-acetylcysteine ameliorates LPS-induced ALI by attenuating neutrophil recruitment through the miR-196b-5p/Socs3 molecular axis. BMC Pulmonary Medicine. 2022;22(1):388.
5. Cui Q, Zhang D, Kong D, et al. Co-transplantation with adipose-derived cells to improve parathyroid transplantation in a mice model. Stem Cell Research & Therapy. 2020;11(1):1-14.
6. Hu Q, Gao M, Zhang D, et al. De novo assembly and transcriptome characterizationNovel insights into the mechanisms of primary ovarian cancer in Microtus fortis. Molecular Medicine Reports. 2022;25(2):1-9.
7. Hu C-B, Jiang H, Yang Y, et al. DL-3-n-butylphthalide alleviates motor disturbance by suppressing ferroptosis in a rat model of Parkinson’s disease. Neural Regeneration Research. 2023;18(1):194.
8. Guo G, Sun L, Yang L, Xu H. IDO1 depletion induces an anti-inflammatory response in macrophages in mice with chronic viral myocarditis. Cell Cycle. 2019;18(20):2598-2613.
9. Pan W, Xu X, Wang Y, Song X. Interleukin?35 reduces inflammation in acute lung injury through inhibiting TLR4/NF?κB signaling pathways. Experimental and Therapeutic Medicine. 2020;19(3):1695-1700.
10. Zhao C, Jiang Q, Chen L, Chen W. LncRNA LINC01535 promotes colorectal cancer development and chemoresistance by sponging miR?761. Experimental and Therapeutic Medicine. 2021;22(1):1-10.
11. Guan X, Xu Y, Zheng J. Long non?coding RNA PCAT6 promotes the development of osteosarcoma by increasing MDM2 expression. Oncol Rep. 2020/12/01 2020;44(6):2465-2474.
12. Meng Q, Wang X, Guo D, et al. Nano-chemically Modified Tetracycline-3 (nCMT-3) Attenuates Acute Lung Injury via Blocking sTREM-1 Release and NLRP3 Inflammasome Activation. ShockInjury, Inflammation, and SepsisLaboratory and Clinical Approaches. 2022;57(5):749-758.
13. Liang P, Liu J, Xiong J, et al. Neural stem cell-conditioned medium protects neurons and promotes propriospinal neurons relay neural circuit reconnection after spinal cord injury. Cell transplantation. 2014;23(1_suppl):45-56.
14. Li Z, Bi H, Jiang H, et al. Neuroprotective effect of emodin against Alzheimer's disease via Nrf2 signaling in U251 cells and APP/PS1 mice. Molecular medicine reports. 2021;23(2):1-1.
15. Ni B, Chen Z, Shu L, et al. Nrf2 Pathway Ameliorates Bladder Dysfunction in Cyclophosphamide-Induced Cystitis via Suppression of Oxidative Stress. Oxidative Medicine and Cellular Longevity. 2021;2021.
16. Jiao Y, Li F, Chen M, et al. Pre-treatment with morphine prevents lipopolysaccharide-induced acute respiratory distress syndrome in rats via activation of opioid receptors. Experimental Cell Research. 2022;418(1):113224.
17. Liu Y, Duan Y, Du D, Chen F. Rescuing Kv10. 2 protein changes cognitive and emotional function in kainic acid-induced status epilepticus rats. Epilepsy & Behavior. 2020;106:106894.
18. Ji L, Guo W. Single-cell RNA sequencing highlights the roles of C1QB and NKG7 in the pancreatic islet immune microenvironment in type 1 diabetes mellitus. Pharmacological Research. 2023/01/01/ 2023;187:106588.
19. Wu M, Gong Y, Jiang L, et al. VEGF regulates the blood?brain barrier through MMP?9 in a rat model of traumatic brain injury. Experimental and Therapeutic Medicine. 2022;24(6):1-10.
20. Hu A, Lu T, Chen D, et al. Vps4b heterozygous mice do not develop tooth defects that replicate human dentin dysplasia I. BMC genetics. 2019;20:1-10.

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